Linkage of vertebral bone marrow fat content with biomechanical strength and trabecular bone structure parameters

نویسندگان

  • Thomas Baum
  • Stefan Ruschke
  • Olga Gordijenko
  • Eduardo Grande Garcia
  • Hendrik Kooijman
  • Rainer Burgkart
  • Ernst J Rummeny
  • Jan S Bauer
  • Dimitrios C Karampinos
چکیده

Linkage of vertebral bone marrow fat content with biomechanical strength and trabecular bone structure parameters Thomas Baum, Stefan Ruschke, Olga Gordijenko, Eduardo Grande Garcia, Hendrik Kooijman, Rainer Burgkart, Ernst J Rummeny, Jan S Bauer, and Dimitrios C Karampinos Department of Radiology, Klinikum rechts der Isar, Technische Universität München, Munich, Bavaria, Germany, Philips Healthcare, Hamburg, Hamburg, Germany, Department of Orthopedics and Orthopedic Sports Medicine, Technische Universität München, Munich, Bavaria, Germany, Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Bavaria, Germany

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Association of MRS-Based Vertebral Bone Marrow Fat Fraction with Bone Strength in a Human In Vitro Model

Bone marrow adiposity has recently gained attention due to its association with bone loss pathophysiology. In this study, ten vertebrae were harvested from fresh human cadavers. Trabecular BMD and microstructure parameters were extracted from MDCT. Bone marrow fat fractions were determined using single-voxel MRS. Failure load (FL) values were assessed by destructive biomechanical testing. Signi...

متن کامل

Fluoride Vol.27 No.4 October 1994 Abstracts 229 MARKED DECREASE IN TRABECULAR BONE QUALITY AFTER FIVE YEARS OF SODIUM FLUORIDE THERAPY - ASSESSED BY BIOMECHANICAL TESTING OF ILIAC CREST BONE BIOPSIES IN OSTEOPOROTIC PATIENTS

from Bone 15 (4) 393-399 1994 Sodium fluoride has for more than 2 decades been a commonly used therapeutic agent for established osteoporosis because of a repeatedly documented anabolic effect on trabecular bone mass. Recently, however, three controlled trials have failed to demonstrate any therapeutic advantage of NaF over placebo with respect to vertebral fracture rate. Also, there have been ...

متن کامل

Gender specific LRP5 influences on trabecular bone structure and strength.

A mutation in LRP5 (low-density lipoprotein receptor-related protein 5) has been shown to increase bone mass and density in humans and animals. Transgenic mice expressing the LRP5 mutation (G171V) demonstrate an increase in bone mass as compared to non-transgenic (NTG) littermates. This study evaluated LRP5 gene and gender-related influences on the structural and biomechanical strength properti...

متن کامل

Presentation of a novel model of chitosan- polyethylene oxide-nanohydroxyapatite nanofibers together with bone marrow stromal cells to repair and improve minor bone defects

Objective(s):Various methods for repairing bone defects are presented. Cell therapy is one of these methods. Bone marrow stromal cells (BMSCs) seem to be suitable for this purpose. On the other hand, lots of biomaterials are used to improve and repair the defect in the body, so in this study we tried to produce a similar structure to the bone by the chitosan and hydroxyapatite. Materials and Me...

متن کامل

Decreased bone strength in HLA-B27 transgenic rat model of spondyloarthropathy.

OBJECTIVE To investigate the nature of osteopenia/osteoporosis in spondyloarthropathy, an inflammatory disorder, using the HLA-B27 transgenic rat model. METHODS HLA-B27 transgenic rats were housed individually and sacrificed at the peak of their disease (8-month-old). The spine and femurs were removed and stored in saline at -20 degrees C until analysis. The bone structure and strength were d...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013